译者:张文静 校对:马丹 审核:张莉芸
Abstract :Diet plays a significant role in the development of gout and hyperuricemia. Gout and hyperuricemia have likewise been associated with the development of cardiovascular disease and -bolic syndrome. Epidemiological studies have shown that certain foods influence levels of serum uric acid and the risk for development of gout.This article reviews the influence of dietary factors on serum uric acid levels and risk of gout, as well as the role of urate transporters in the development of hyperuricemia and gout.Various epidemiological studies have shown the effects of certain foods on the risk of developing gout and hyperuricemia. Low-fat dairy products, purine-rich vegetables, whole grains, nuts and legumes, and less sugary fruits, coffee and vitamin C supplements decrease the risk, whereas intake of red meat, fructose-containing beverages and alcohol increase the risk of gout. There is also an increased although basic understanding of the effects of vitamin C, alcohol and fructose on urate transporters. Certain foods can lead to a decreased or increased risk of development of gout and hyperuricemia. Advances have established the interplay of certain foods on urate transporters and renal handling of urate. More studies, especially prospective ones, are needed to increase our understanding of the roles of foods and urate transporters and other molecular mechanisms on the risk of developing gout and hyperuricemia.
摘要:饮食在痛风和高尿酸血症发生发展中发挥了重要作用。同样,痛风和高尿酸血症与心血管疾病及代谢综合征的发生相关。流行病学研究显示,某些食物影响尿酸水平,是发生痛风的危险因素。本文综述了食物对血尿酸水平和痛风风险的影响,以及尿酸转运在高尿酸血症及痛风发展中发挥的作用。不同的流行病学研究显示,某些食物在痛风和高尿酸血症发生风险中发挥了作用。低脂牛奶、富含嘌呤的蔬菜、全麦食物、坚果、豆类、低糖水果、咖啡和维生素C可降低痛风风险,而摄入红肉、富含果糖的饮料和酒精可增加痛风风险。我们对维生素C、酒精和果糖对尿酸转运的影响了解越来越多,但仅限于基本了解。某些食物可导致痛风和高尿酸血症发生风险增高或降低,也进一步证实了这些食物对尿酸转运和肾脏处理尿酸的作用。为了增加我们对食物、尿酸转运及其他分子机制对痛风和高尿酸血症发生风险影响的了解尚需更多的研究,尤其是前瞻性的研究。
引自:Torralba KD, De Jesus E, Rachabattula S. The interplay between diet, urate transporters and the risk for gout and hyperuricemia: current and future directions. Int J Rheum Dis. 2012,15(6):499-506.