前言：目的　探讨大型垂体腺瘤的根治方法与手术安全性。　方法 1999年 1月～ 2 0 0 2年 4月我院对 14例大型、巨大型垂体腺瘤采用一侧眶 -额下入路手术 ,尽可能充分地切除肿瘤 ,至少做到将肿瘤的鞍上部分完全切除。术后 1 5～ 3 5个月内X刀进一步治疗鞍内残瘤。　结果　肿瘤全切除 4例 ,鞍内残留 10例 ,无一例出现严重手术并发症。 8例残瘤术后行X刀治疗 ,未出现视力损害和垂体功能减退。X刀补充治疗的 8例随访 5～ 2 6个月 ,平均 14 8个月 ,无一例肿瘤复发。　结论眶-额下入路手术操作方便 ,利于充分切除肿瘤和减少手术并发症。术后加行X -刀治疗可能控制肿瘤复发。

-ive To assess

the technique and the safety of radical resection for large pituitary adenoma.

Methods Unilateral transorbital subfrontal approach operations were employed for

treating 14 cases of large or giant pituitary adenomas. Tumors, at least the

suprasellar extension of them, were removed as thoroughly as possible in

surgery. Then the X-knife was administered for intrasellar residual lesions

1.5～3.5 months after the surgery. Results Total removal of tumors was achieved

in 4 patients, while intras...