Childhood onset psoriasis: association with future cardiovascular and -bolic comorbidities

翻译研究生：范秋玉 校对人：乔鹏燕 审核人：张莉芸

Psoriasis is associated with higher prevalences of cardiovascular and -bolic comorbidities in adults but the relationship of age of onset and those prevalences is unknown.To evaluate whether childhood onset of psoriasis (COP) is correlated with the frequencies of cardiovascular and -bolic comorbidities in adulthood.This non-interventional, cross-sectional, multicenter study on adults with psoriasis was conducted in 29 dermatology centers in France. Data on sex, age at psoriasis onset and its clinical characteristics, and cardiovascular risk factors, including weight, body mass index, waist circumference, dyslipidemia, diabetes, hypertension, smoking, and personal / familial major adverse cardiovascular event (MACE) were systematically recorded.2,201 psoriasis patients (male: 56·3%; mean age: 48·7 years; 24·8% with COP) were consecutively included in the study. Univariate analysis showed that COP was associated with lower frequencies of obesity, high waist circumference, diabetes, dyslipidemia, hypertension, familial cardiovascular disease, MACE, and -bolic syndrome, but more frequent active smoking. Multivariate analysis retained sex, as being associated with cardiovascular and -bolic comorbidities frequencies, and age with smoking, but not age at psoriasis onset. Psoriasis severity was associated with higher frequencies of obesity and psoriatic arthritis.Our results showed that COP does not seem to be an additional risk factor for higher frequencies of cardiovascular and -bolic comorbidities during adulthood.

研究显示成人银屑病与其心血管和代谢性疾病的高发生率有关。但是银屑病的发病年龄与其成年心血管和代谢性疾病的发病率之间的关系还不确切。评估幼年银屑病的发病率是否与其成年高发的心血管和代谢性疾病有关。法国做了一项关于成人银屑病非干预性、横断面、多中心研究，研究中系统的记录来自29个皮肤科银屑病患者发病的性别、年龄和其临床特点、心血管危险因素(包括体重、体重指数、腰围、血脂异常、糖尿病、高血压、吸烟和个人或家族史)等数据。入组的2201位银屑病患者中，男性占56.3%，儿童占24.8%，平均年龄为48.7岁。通过单因素变量分析显示幼年银屑病的发病率与肥胖、腰围、糖尿病、血脂异常、高血压、心血管病家族史和代谢综合征关系不大，但与吸烟关系密切。多因素变量分析显示银屑病患者的发生率与心血管和代谢性疾病及吸烟的年龄有关，而与银屑病的发病年龄无关。银屑病的疾病活动度与肥胖和银屑病关节炎的高发病率有关。我们的研究显示：幼年银屑病的发病率似乎不能成为其成年心血管和代谢性疾病高发生率的一种危险因素。