中医药辨证治疗冠心病抗氧化的研究

摘要：中医采用不同制剂如汤剂、中成药、中药针剂等辨证治疗可以明显改善冠心病抗氧化功能,但仍需根据患者各自病情辨证施治,选择恰当的药物,深入研究中药作用机理,加强基础研究。

关键词：冠心病;抗氧化;中医药疗法;中成药;

The research of syndrome differentiation of traditional Chinese medicine treating the coronary heart disease by resisting oxidation

ZHAO Fengyi1 HAN Xu2

(1.Nanjing university of Chinese medicine, 2. Chinese medicine hospital Jiangsu province

Nanjing, Jiangsu province, 210038)

Abstract：There are different preparations of traditional Chinese medicine, such as medicinal broth, proprietary Chinese medicine, Chinese medicine injection can obviously improve antioxidant function of coronary heart disease diagnosis, but still need to be according to their respective patient evidence-d medicine, choosing the right drugs, further study of mechanism of Chinese medicine, to strengthen basic research.

Keywords:Coronary heart disease (CHD);Antioxidant; Traditional Chinese medicine therapy; Chinese patent medicine;

冠心病是严重危害人类健康的一类常见疾病。中医认为冠心病心绞痛属于中医“胸痹”、“心痛”范畴，其发病机制为本虚标实。现代医学认为冠心病系冠状动脉粥样硬化使血管腔阻塞,或功能性改变(痉挛)导致心肌缺血、缺氧而引起的心脏病。研究[1]表明,氧自由基产生过多和(或)清除能力下降导致氧化—抗氧化失衡,是心肌缺血发病的重要机制,氧自由基参与组织损伤有关,其产物为过氧化脂质(LPO), 它参予炎症反应,导致血管动脉硬化,甚至引起细胞死亡。机体为防御自由基损伤,有一系列保护酶类,如超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶 (GSH—PX),过氧化氢酶(CAT)[2]。近年来，抗氧化治疗已经成为冠心病治疗的新方向。

1.口服中药

1.1中药治疗

闫凌云，张玉泉等[3]在论证老年冠心病中西医基本病机的基础上,研究补虚化瘀祛痰饮组方构成的抗氧化作用机制。结果示：对照组患者治疗前、后血浆SOD活性及LPO含量无显著性差异(P>0105),中药干预组患者治疗后血浆SOD活性显著升高, LPO含量显著降低(P